Контроль гіпотетичного прояву хронічного синдрому втоми: попередні спостереження

 

TABLE 6

Correlation Analysis Between the RNase-L Ratio and the Electrolytes with the Acute Phase Reaction Markers and the Immune Cell Counts and Percentages in the CFS Patients

ParameterRNase-LWBK+% WBK+SK+NSK+SK+NSK+SCa++

RNase-L-

WBK+0, 058-

% WBK+0, 2330, 255-

S K+-0, 0150, 379-0, 275-

NSK+0, 0570, 999****0, 2680, 348-

S K+ NS K+0, 0640, 963***0, 355-0, 2770, 268-

SCa+ +-0, 0180, 414*-0, 3250, 3520, 409*0, 343-

SNa+0, 0360, 0340, 079-0, 2120, 0360, 095-0, 105

CRP0, 021-0, 105-0, 0260, 004-0, 105-0, 1130, 342

ESR0, 004-0, 439**0, 004-0, 239-0, 433*-0, 398*-0, 030

 

CD3- CD56+% -0, 618****0, 079-0, 2180, 0600, 2090, 2020, 374

CD3- CD56+-0, 510***-0, 018-0, 1370, 080-0, 020-0, 0420, 354

CD8+0, 401 *-0, 0170, 102-0, 051-0, 015-0, 0030, 123

% CD3+0, 388 *0, 0590, 1150, 0610, 0610, 049-0, 300

CD25+0, 050-0, 3730, 109-0, 001-0, 376-0, 399*-0, 186

% CD19+CD5+-0, 1170, 0330, 399*-0, 1440, 032-0, 071-0, 055

% CD4+

CD45RA-0, 163-0, 2330, 243-0, 178-0, 232-0, 200-0, 404*

Statistical Method: Pearson product moment correlations.

* = P < 0. 04, « = P < 0. 03, *** = P < 0. 007, **** = P < 0. 001.

WBK = Whole body K+, SK+ = Serum K+, NS K+ = Non-serum K+, S Ca = Serum Ca++.

 

Table 7 shows the multiple regression analysis of the association between the major immune cell differences between CFS patients and controls and the serum and biochemical markers. Significantly higher RNase-L ratio and lower serum calcium levels characterized CFS-patients with decreased NK-cells. Conversely the increases in the CD 19+ and CD 19+ CD5+ cell levels were prominently associated with increases in the ESR and whole body potassium levels. The levels of the CD25+ cells were not associated with significant regression models and the associations with the measured variables were very weak.

 

 

More than fifty percent of the sample (51. 8) showed an abnormal whole body potassium level (10% of expected normal value). Eight patients had increased, while six presented with reduced potassium levels

 

TABLE 7

Regression Analysis of the Association Between the Major Immune Cell Changes and Acute Phase Reaction Markers and the Electrolytes in the CFS Patients

Cell CountsPercentage Distribution

CD3- CD56+

Model: R2 = 0. 379. F = 7. 32, P< 0. 004 Variables

RNase-L R (-) P< 0. 005

Serum Ca++ (+) P<0. 05Model: R2 = 0. 567. F = 10. 03, P< 0. 0002 Variables

RNase-L R (-) P< 0. 0002

Serum Ca++ (+) P < 0. 006

3) CRP (-) P<0. 11

CD19+

Model: R2 = 0. 244, F = 3. 88, P< 0. 04 Variables

1) ESR (+) P<0. 05

2) CRP (+) P<0. 32Model: R2 = 0. 189, F = 5. 85, P< 0. 03 Variables

1) ESR (+) P<0. 02

CD19+CD5+

Model: R2 = 0. 416, F « 3. 92, P< 0. 02 Variables

ESR (+) P<0. 03

% Whole body K+ (+) P < 0. 03

CRP (+) P<0. 23

SerumNa+ (+) P<0. 28Model: R2 = 0. 412, F = 3. 86, P< 0. 02 Variables

ESR (+) P<0. 02

% Whole body K+ (+) P < 0. 02 3

RNase-L R (-) P<0. 19

SerumNa+ (+) P<0. 31

CD25+

Model: R2 = 0. 346, F = 2. 22, P < 0. 09 Variables

Ser. K+: Non-Ser. K+ (-) P<0. 04

% Whole body K+ (+) P<0. 15

CRP (+) P<0. 30

SerumNa+ (+) P<0. 25

Serum K+ (+) P<0. 29Model: R2 = 0. 183, F = 2. 69, P< 0. 09 Variables

Serum Ca++ (-) P<0. 07

Ser. K+: Non-Ser. K+ (-) P< 0. 23

Statistical Method: Forward stepwise multiple regression

 

Although we have studied only a small sample, these results suggest that whole body potassium content is likely to be abnormal in CFS-pa-tients. However, we were not able to confirm earlier reports on significantly depleted whole body potassium content in CFS-patients compared to controls (6, 7, 12). Preedy and colleagues found only one whole body potassium depletion in 23 female CFS-patients (35). We conclude abnormal whole body potassium might be characteristic for subsets